These contemporary instruments deployed in specialized central laboratories are not always accessible for continuous preventive monitoring; their utilization is generally limited to reactive healthcare. Integrated devices aim to miniaturize the analytical processes followed in the central laboratories in a cost-effective manner by incorporating fluidic, electronic, mechanical, and chemical components within a single unit. The philosophy of the integrated design aims to unify the sample collection, preparation, analysis and post-processing to enable the “sample in–answer out” testing required for distributed proactive healthcare. In this regard, non-invasive sampling offers easy access to the physiologically relevant biomarkers with minimum discomfort and supervision. In clinical practice, however, there are many uncertainties regarding the diagnostic correspondence of the measured concentrations in non-invasive samples and how these concentrations are correlated to the more familiar blood-based counterparts.

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