In this content, both the newer noninvasive (ie, those that pose no breach of an epithelial barrier) and minimally invasive techniques relevant to the treatment of the critically ill or injured patient will be discussed. In some cases, the development of the technology is so recent that published data describing their clinical applications may be scant. The emphasis herein is on newer technologies; therefore, the discussion of certain established noninvasive techniques, such as pulse oximetry, and minimally invasive therapies, such as percutaneous abscess drainage, will be deferred. Critically ill and injured patients are some of the most difficult patients to treat in the hospital. These patients frequently harbor complex multiorgan pathologic processes that require close monitoring of hemodynamics and critical organ function to avoid further morbidity or mortality. The primary derangements to avoid are impaired tissue perfusion and cellular hypoxia, which have been associated with nosocomial infection and multiple organ failure. The occurrence of these morbidities severely impairs the chances of a good outcome. Therefore, timely intervention for any physiologic perturbation is often crucial.

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